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  2. Treatment-resistant depression - Wikipedia

    en.wikipedia.org/wiki/Treatment-resistant_depression

    Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]

  3. Vagus nerve stimulation may relieve treatment-resistant ... - AOL

    www.aol.com/those-treatment-resistant-depression...

    Vagus nerve stimulation therapy improved the symptoms of treatment-resistant depression for nearly 500 participants in a major clinical trial. ... knowing all other options had failed, Nick’s ...

  4. 6 different subtypes discovered for depression: How that may ...

    www.aol.com/lifestyle/6-different-subtypes...

    Treatment-resistant depression is when a person’s depression doesn’t respond to at least two different types of antidepressants. About 30% of people with major depressive disorder do not ...

  5. Breakthrough antidepressants with fewer side effects could ...

    www.aol.com/finance/breakthrough-antidepressants...

    The FDA approved Johnson & Johnson’s drug for treatment-resistant depression in 2019. Esketamine is derived from a pediatric anesthetic called ketamine. Through research pioneered at Yale ...

  6. Management of depression - Wikipedia

    en.wikipedia.org/wiki/Management_of_depression

    The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

  7. List of investigational antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_investigational...

    This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among others.

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