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Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation in conjunction with tissue factor (TF/factor III) in the extrinsic pathway.
2155 14068 Ensembl ENSG00000057593 ENSMUSG00000031443 UniProt P08709 P70375 RefSeq (mRNA) NM_000131 NM_001267554 NM_019616 NM_010172 RefSeq (protein) NP_000122 NP_001254483 NP_062562 NP_034302 Location (UCSC) Chr 13: 113.11 – 113.12 Mb Chr 8: 13.08 – 13.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is a ...
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene. [ 5 ] GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos .
The difficulty of obtaining populations of viable B cell precursors was resolved by the design of a long-term bone marrow culture system, which secreted LP1 growth factor. [5] In given populations, it was determined that B cells could be sorted into groups of "activated" and "resting" cells by their size, enabling the study of factors on these ...
Alternatively, phenotyping DPD using ex-vivo enzymatic assay or surrogate testing (i.e., monitoring physiological dihydrouracil to uracil ratio in plasma) has been presented as a possible upfront strategy to detect DPD deficiency. 5-FU test dose (i.e., preliminary administration of a small dose of 5-FU with pharmacokinetics evaluation) has been ...
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
14178 Ensembl ENSG00000140285 ENSMUSG00000027208 UniProt P21781 P36363 RefSeq (mRNA) NM_002009 NM_008008 RefSeq (protein) NP_002000 NP_032034 Location (UCSC) Chr 15: 49.42 – 49.49 Mb Chr 2: 125.88 – 125.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene. Function The protein encoded by this gene is ...
The deficiency leads to decreased activity in the intrinsic pathway (F-IX) factors, monitored by PTT, and the extrinsic pathway (F-VII) which PT monitors. However, factor VII has the shortest half-life of all the factors carboxylated by vitamin K; therefore, when deficient, it is the PT that rises first, since the activated Factor VII is the ...