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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
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One common off-label use for topiramate is in the treatment of bipolar disorder. [ 25 ] [ 26 ] [ 27 ] A review published in 2010 suggested a benefit of topiramate in the treatment of symptoms of borderline personality disorder , however the authors noted that this was based only on one randomized controlled trial and requires replication.
Ozempic has taken the world by storm – largely due to the medication's weight loss effect and rumored use by celebrities and the wealthy.. But some physicians want to shift this narrative ...
Here are links to possibly useful sources of information about Dofetilide. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
[15] [16] From 2015 to 2017, 12.6% of women aged 15–49 in the US reported using combined oral contraceptive pills, making it the second most common method of contraception in this age range (female sterilization is the most common method). [17] Use of combined oral contraceptive pills, however, varies widely by country, [18] age, education ...
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In humans, coital vocalizations are linked to sexual pleasure or sexual gratification and orgasm, [8] hence occurring during copulation and serving as an expression of sexual pleasure. Vocalizations can be used intentionally by women in order to boost the self-esteem of their partner and to cause quicker ejaculation .