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Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load. [8] This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once.
[1] [5] They are the most common type of worm infection in Western Europe, Northern Europe and the United States. [5] School-aged children are the most commonly infected. [1] In the United States about 20% of children will develop pinworm at some point. [3] Infection rates among high-risk groups may be as high as 50%. [2]
ATC code P02 Anthelmintics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Pyrantel pamoate – effective against most parasitic nematodes of the GIT; Macrocyclic lactones are glutamate-gated chloride channel agonists, [8] and include: Avermectins (including ivermectin and moxidectin) - effective against most common intestinal worms, except tapeworms, for which praziquantel is commonly used in conjunction for mass ...
Pharmaceutical drugs formulated this way include cycloguanil pamoate, hydroxyzine pamoate, imipramine pamoate, olanzapine pamoate hydrate, oxantel pamoate, pyrantel pamoate, and pyrvinium pamoate. Pamoic acid has agonist activity for the orphan G protein-coupled receptor GPR35 by which it activates ERK and beta-arrestin2 , and causes ...
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The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children [1] or EMLc [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.
Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. [2] [3] Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α. [4] [5] Pyrvinium salts can also inhibit the growth of cancer cells. [6]