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Budesonide/formoterol, sold under the brand name Symbicort among others, is a fixed-dose combination medication used in the management of asthma or chronic obstructive pulmonary disease (COPD). [2] It contains budesonide , a steroid ; and formoterol , a long-acting β 2 -agonist (LABA). [ 2 ]
[49] [50] When nebulized, budesonide has an bioavailability of 6% and reaches C max within 1–3 hours. [50] [49] When formulated as a rectal foam, budesonide has an bioavailability of 3% to 27% and reaches C max around 1.5 hours. [51] The plasma protein binding of budesonide is around 85-90%, with an apparent volume of distribution of 2.2-3.9L/kg.
An inhaler (puffer, asthma pump or allergy spray) is a medical device used for delivering medicines into the lungs through the work of a person's breathing. This allows medicines to be delivered to and absorbed in the lungs, which provides the ability for targeted medical treatment to this specific region of the body, as well as a reduction in the side effects of oral medications.
In this case, the main compounds used are beclometasone, budesonide, fluticasone, mometasone and ciclesonide. In rhinitis, sprays are used. For asthma, glucocorticoids are administered as inhalants with a metered-dose or dry powder inhaler. [39] In rare cases, symptoms of radiation induced thyroiditis has been treated with oral glucocorticoids ...
Each inhalation delivers 0.4 to 0.5 mg (400 to 500 μg) in 800 mL of air. [4] [2] [5] Use is not to exceed three days. [2] Historically, it has also been used for weight loss in oral tablet preparations at a dose of 25 mg. [6] [7] No medications containing propylhexedrine are currently approved for weight loss in any country since roughly 1976. [8]
For ozone (O 3), the guidelines suggest values no higher than 100 μg/m 3 for an 8-hour mean and 60 μg/m 3 peak season mean. [2] For nitrogen dioxide (NO 2), the guidelines set 10 μg/m 3 for the annual mean or 25 μg/m 3 for a 24-hours mean. [2] For sulfur dioxide (SO 2), the guidelines stipulate concentrations not exceeding 40 μg/m 3 24 ...
[3] [10] Blood lead levels 50 to 1,000 times higher than preindustrial levels are commonly measured in contemporary human populations around the world. [3] The National Academies evaluated this issue [ 12 ] in 1991 and confirmed that the blood lead level of the average person in the US was 300 to 500 times higher than that of pre-industrial humans.
A single preovulatory 10-mg dose of mifepristone delays ovulation by three to four days and is as effective an emergency contraceptive as a single 1.5-mg dose of the progestin levonorgestrel. [ 55 ] In women, mifepristone at doses greater or equal to 1 mg/kg antagonizes the endometrial and myometrial effects of progesterone.
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