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  2. Myocardial contractility - Wikipedia

    en.wikipedia.org/wiki/Myocardial_contractility

    Heart rate; Conduction velocity; Preload; Afterload; Contractility; By this model, if myocardial performance changes while preload, afterload, heart rate, and conduction velocity are all held constant, then the change in performance must be due to a change in contractility. However, changes in contractility alone generally do not occur.

  3. Cardiac excitation-contraction coupling - Wikipedia

    en.wikipedia.org/wiki/Cardiac_excitation...

    These cells, unlike most other cells within the heart, can spontaneously produce action potentials. [5] These action potentials travel along the cell membrane (sarcolemma) , as impulses, passing from one cell to the next through channels, in structures known as gap junctions .

  4. Endocardial cushions - Wikipedia

    en.wikipedia.org/wiki/Endocardial_cushions

    The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial-mesenchymal transition, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards the interior of the heart tube). These migrated cells form the "swellings" called the endocardial cushions seen in ...

  5. Endochondral ossification - Wikipedia

    en.wikipedia.org/wiki/Endochondral_ossification

    The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components. Thus, the initial hyaline cartilage template is ...

  6. Cardiac physiology - Wikipedia

    en.wikipedia.org/wiki/Cardiac_physiology

    The cardiomyocytes make up the bulk (99%) of cells in the atria and ventricles. These contractile cells respond to impulses of action potential from the pacemaker cells and are responsible for the contractions that pump blood through the body. The pacemaker cells make up just (1% of cells) and form the conduction system of the heart.

  7. Ventricular remodeling - Wikipedia

    en.wikipedia.org/wiki/Ventricular_remodeling

    The cardiac myocyte is the major cell involved in remodeling. Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for remodeling is after myocardial infarction. There is myocardial necrosis (cell death) and disproportionate thinning of the heart. This thin, weakened area is ...

  8. Cardiac cycle - Wikipedia

    en.wikipedia.org/wiki/Cardiac_cycle

    In a healthy heart all activities and rests during each individual cardiac cycle, or heartbeat, are initiated and orchestrated by signals of the heart's electrical conduction system, which is the "wiring" of the heart that carries electrical impulses throughout the body of cardiomyocytes, the specialized muscle cells of the heart.

  9. Anrep effect - Wikipedia

    en.wikipedia.org/wiki/Anrep_effect

    The heart adjusts its pumping efficiency through changes in muscle length and load. When the cardiac muscle is stretched, it triggers a biphasic rise in force generation. The initial phase, governed by the Frank-Starling law (heterometric autoregulation), results in an immediate increase in contractile strength due to increased end-diastolic ...