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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
Molecular Biology of the Cell has been described as "the most influential cell biology textbook of its time". [2] The sixth edition is dedicated to the memory of co-author Julian Lewis, who died in early 2014. The book was the first to position cell biology as a central discipline for biology and medicine, and immediately became a landmark ...
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Principles of Biology is a college level biology electronic textbook published by Nature Publishing in 2011. The book is not a digitally reformatted version of a paper book. [ 1 ] The book, the first in a projected series, is Nature Publishing's first foray into textbook publishing.
The biology texts they developed covered evolutionary theory, which was by this time overwhelmingly accepted as biology's central organizing principle. These books became widely used in the nation's high schools, and as a consequence, the public controversy about the teaching of evolution in public schools re-ignited.
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