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Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma. [5]It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and ...
Cocaine stimulates the mesolimbic pathway in the brain. [15] Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. [12] Physical effects may include a fast heart rate, sweating, and dilated pupils. [12] High doses can result in high blood pressure or high body temperature. [16]
What is a beta blocker? Churchwell said the drug class slows the heart by inhibiting and binding to beta one and beta two receptors on the heart. They limit the production of epinephrine ...
The findings indicate the drugs could be considered as a way to manage aggression and hostility in people with psychiatric conditions.
Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...
diazepam, benzodiazepines, beta blockers, anti-hypertensives An adrenergic storm is a sudden and dramatic increase in serum levels of the catecholamines adrenaline and noradrenaline (also known as epinephrine and norepinephrine respectively), with a less significant increase in dopamine transmission.
It is lipid soluble and also has sodium channel-blocking effects. Propranolol is a non-selective β-adrenergic receptor antagonist, or beta blocker; [61] that is, it blocks the action of epinephrine (adrenaline) and norepinephrine (noradrenaline) at both β 1-and β 2-adrenergic receptors.