When.com Web Search

Search results

1. Results From The WOW.Com Content Network

2. Sodium/glucose cotransporter 2 - Wikipedia

   en.wikipedia.org/wiki/Sodium/glucose_cotransporter_2

   6524 246787 Ensembl ENSG00000140675 ENSMUSG00000030781 UniProt P31639 Q923I7 RefSeq (mRNA) NM_003041 NM_133254 RefSeq (protein) NP_003032 NP_573517 Location (UCSC) Chr 16: 31.48 – 31.49 Mb Chr 7: 127.86 – 127.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 ...

3. Sodium-glucose transport proteins - Wikipedia

   en.wikipedia.org/wiki/Sodium-glucose_transport...

   [2] [3] In addition to SGLT1 and SGLT2, there are 10 other members in the human protein family SLC5A. [4] SLC5A4, also known as SGLT3, is a member of the sodium-glucose cotransporter family. Unlike SGLT1 and SGLT2, which are efficient glucose transporters, SGLT3 functions primarily as a glucose sensor rather than a transporter.

4. SGLT2 inhibitor - Wikipedia

   en.wikipedia.org/wiki/SGLT2_inhibitor

   Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...

5. Glucose transporter - Wikipedia

   en.wikipedia.org/wiki/Glucose_transporter

   It is responsible for the low level of basal glucose uptake required to sustain respiration in all cells. Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. GLUT1 expression is upregulated in many tumors. GLUT2: Is a bidirectional transporter, allowing glucose to flow in 2 directions.

6. Discovery and development of gliflozins - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   SGLT-2 is a member of the glucose transporter family and is a low-affinity, high-capacity glucose transporter. SGLT-2 is mainly expressed in the S-1 and S-2 segments of the proximal renal tubules where the majority of filtered glucose is absorbed. SGLT-2 has a role in regulation of glucose and is responsible for most glucose reabsorption in the ...

7. Ipragliflozin - Wikipedia

   en.wikipedia.org/wiki/Ipragliflozin

   Ipragliflozin (INN, [2]: 69 trade names Suglat) is a pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin, jointly developed by Astellas Pharma and Kotobuki Pharmaceutical, was approved in Japan on January 17, 2014, [3] and in Russia on May 22, 2019. [4] Ipragliflozin is a Sodium/glucose cotransporter 2 (SGLT2) inhibitor . [5]