Search results
Results From The WOW.Com Content Network
Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
Because of a high immunogenicity of polyclonal antibodies, almost all patients have an acute reaction to the treatment. It is characterized by fever, rigor episodes, and even anaphylaxis. Later during the treatment, some patients develop serum sickness or immune complex glomerulonephritis. Serum sickness arises seven to fourteen days after the ...
CD20 is a protein that is found on the surface of B-cells and thus serves as an important target in the treatment of many B-cell malignances, including CLL. [45] Some CD20 antibodies that have been used for the treatment of CLL include: [45] Rituximab; Ofatumumab; Obinutuzumab
Signs include vomiting, diarrhea, collapse, difficulty breathing, and body temperature approaching 42 °C to 43 °C. Treatment includes cooling the dogs with wet towels and fans, intravenous fluid therapy, and other supportive care. [171] If a dog's temperature begins to drop to around 40 °C, stop the cooling process.
Multiple myeloma has been diagnosed in dogs, [157] cats, and horses. [158] In dogs, multiple myeloma accounts for around 8% of all haemopoietic tumors. Multiple myeloma occurs in older dogs and is not particularly associated with either males or females. No breeds appear overrepresented in case reviews that have been conducted. [159]
Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, joint pain, fever, and lymphadenopathy.
Rituximab combined with methotrexate appears to be more effective in improving symptoms compared to methotrexate alone. [133] Rituximab works by decreasing levels of B-cells (immune cell that is involved in inflammation). People taking rituximab had improved pain, function, reduced disease activity and reduced joint damage based on x-ray images.
However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [15] and a normal bleeding time does not exclude a platelet disorder. [16] Bone marrow examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt. [12]