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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
Because of a high immunogenicity of polyclonal antibodies, almost all patients have an acute reaction to the treatment. It is characterized by fever, rigor episodes, and even anaphylaxis. Later during the treatment, some patients develop serum sickness or immune complex glomerulonephritis. Serum sickness arises seven to fourteen days after the ...
CD20 is a protein that is found on the surface of B-cells and thus serves as an important target in the treatment of many B-cell malignances, including CLL. [45] Some CD20 antibodies that have been used for the treatment of CLL include: [45] Rituximab; Ofatumumab; Obinutuzumab
Passive anti-Aβ mAb treatment can be used for preventive attempts to modify AD progression before it causes extensive brain damage and symptoms. Trials using mAb treatment for patients positive for genetic risk factors, and elderly patients positive for indicators of AD are underway.
Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, joint pain, fever, and lymphadenopathy.
Treatment may involve one or more of the following: chemotherapy, radiation therapy, proton therapy, targeted therapy, and surgery. [ 1 ] [ 2 ] In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. [ 2 ]
Breed, lack of water, exercise, and high ambient temperature predispose dogs to heat stroke. Signs include vomiting, diarrhea, collapse, difficulty breathing, and body temperature approaching 42 °C to 43 °C. Treatment includes cooling the dogs with wet towels and fans, intravenous fluid therapy, and other supportive care. [171]
A more detailed summary of current treatment options can be found at Treatment Options. The following medications should probably be avoided: Midazolam - Can cause irritability. Melatonin - Is known to stimulate the immune system. Also, see "An Innovative Approach to the Problem of Sedating Children with Opsoclonus-Myoclonus Syndrome".