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Administering a vaginal tablet without an applicator. Intravaginal administration is a route of administration where the substance is applied inside the vagina . Pharmacologically , it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix ) with limited systemic ...
Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to oxytocin, but was associated with uterine hyperstimulation. [15] Misoprostol is an agonist of EP1 and EP3 receptors, and can cause a greater stimulation at lower concentrations.
Misoprostol also may be used in conjunction with oxytocin. [24] Between 2002 and 2012, a misoprostol vaginal insert was studied, and was approved in the EU. [25] [26] [27] It was not approved for use in the United States, and the US FDA still considers cervical ripening and labor induction to be outside of the approved uses for misoprostol. [28 ...
For pregnancies after 9 weeks, two doses of misoprostol (the second drug) makes the treatment more effective. [21] From 10 to 11 weeks of pregnancy, the National Abortion Federation suggests second dose of misoprostol (800 micrograms) four hours after the first dose. [22] After the patient takes mifepristone, they must also administer the ...
The use of misoprostol has been extensively studied but normally in small, poorly defined studies. Only a very few countries have approved misoprostol for use in induction of labor. [citation needed] Intravenous (IV) administration of synthetic oxytocin preparations is used to artificially induce labor if it is deemed medically necessary. [1]
It can be used to administer drugs affecting uterus motility, such as oxytocin and prostaglandins, e.g. in labor induction or medical abortion. [1] References
Prostaglandin E 2 (PGE 2) is used to induce labor and should not be used in people that are contraindicated to give birth vaginally or spontaneous labor. [25] PGE 2 should not be used in people with allergies to prostaglandins or any components in the drugs formulations. [4] PGE 2 should be stopped before other oxytocic agents like oxytocin are ...
Misoprostol (Cytotec): A synthetic prostaglandin E1 analog oral medication that can stimulate uterine contractions. Misoprostol does not need to be refrigerated because it is heat stable. It is easy to administer compared with oxytocin and ergot alkaloids in low-resource areas where refrigeration and sterile needles are not available. [26]