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DCIS has been classified according to the architectural pattern of the cells (solid, cribriform, papillary, and micropapillary), tumor grade (high, intermediate, and low grade), or the presence or absence of comedo histology; [8] or, in the case of the apocrine cell-based in situ carcinoma, apocrine ductal carcinoma in situ, it may be ...
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
The rate of death due to breast carcinoma was also influenced by grade, with 90% occurring in 40, 13, and 8 years among patients with grades 1, 2, and 3 tumors, respectively.” [12] [30] Immunohistochemistry of breast cancer (Infiltrating ductal carcinoma of the breast) assayed with anti HER-2 (ErbB2) antibody.
The 5-year relative survival rate drops to 22% for women with stage IV breast cancer. [3] In cancer types with high survival rates, incidence is usually higher in the developed world, where longevity is also greater. Cancers with lower survival rates are more common in developing countries. [6]
The grading of a cancer in the breast depends on the microscopic similarity of breast cancer cells to normal breast tissue, and classifies the cancer as well differentiated (low-grade), moderately differentiated (intermediate-grade), and poorly differentiated (high-grade), reflecting progressively less normal appearing cells that have a ...
DCIS can be differentiated into groups based on low, intermediate, and high grade. When comparing the growth potential of normal epithelial cells to DCIS, it is 10 times larger, and the apoptosis rate was also 15 times greater. Furthermore, comedo-type DCIS usually causes necrosis in the duct center and has a more significant threat of ...
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