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The difference here is that tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a GLP-1 receptor agonist. That means Mounjaro targets two receptors in the body ...
To break it down a bit more, Mounjaro activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, which are naturally occurring hormones found in ...
“Tirzepatide stimulates GLP-1 and GIP receptors, making it the first medication in its class to target both GIP and GLP-1 receptors.” The body naturally produces GIP and GLP-1, which Ngo ...
A large study published in Nature Medicine reviewed the effects of GLP-1 drugs like Ozempic and Mounjaro on 175 different health outcomes. The findings show benefits for brain and heart health ...
At the GLP-1 receptor, though, tirzepatide shows bias towards cAMP (a messenger associated with regulation of glycogen, sugar, and lipid metabolism) generation, rather than β-arrestin recruitment. This combination of preference towards GIP receptor and distinct signaling properties at GLP-1 suggest this biased agonism increases insulin ...
The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene. [ 5 ] [ 6 ] GIP-R is a member of the class B family of G protein coupled receptors . [ 7 ]