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  2. List of drugs granted breakthrough therapy designation

    en.wikipedia.org/wiki/List_of_drugs_granted...

    Treatment of adults with locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC) whose disease has not progressed during or following concurrent or sequential platinum-based chemoradiation therapy and whose tumors have EGFR exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test [2]

  3. Gefitinib - Wikipedia

    en.wikipedia.org/wiki/Gefitinib

    A pre-planned sub-group analyses showed that progression-free survival (PFS) was significantly longer for gefitinib than chemotherapy in patients with EGFR mutation positive tumours (HR 0.48, 95 per cent CI 0.36 to 0.64, p less than 0.0001), and significantly longer for chemotherapy than gefitinib in patients with EGFR mutation negative tumours ...

  4. Pembrolizumab - Wikipedia

    en.wikipedia.org/wiki/Pembrolizumab

    Micrograph showing a PD-L1 positive non-small cell lung carcinoma. PD-L1 immunostain. As of 2019, pembrolizumab is used via intravenous infusion to treat inoperable or metastatic melanoma, metastatic non-small cell lung cancer (NSCLC) in certain situations, as a first-line treatment for metastatic bladder cancer in patients who cannot receive cisplatin-based chemotherapy and have high levels ...

  5. Cancer breakthrough as groundbreaking trials see seriously ...

    www.aol.com/groundbreaking-cancer-trials-see...

    Dr Searle added: “These drugs are a huge breakthrough in this type of cancer, allowing patients without standard treatment options to achieve remission, in many cases for months or years.

  6. Pfizer drug extends life for patients with rare lung cancer ...

    www.aol.com/news/pfizer-drug-extends-life...

    Non-small cell lung cancers account for about 85% of lung cancer diagnoses, and ALK-positive cancers account for about 4% of those diagnoses — more than 70,000 people every year.

  7. Hospitals begin offering breakthrough radiation therapy for ...

    www.aol.com/news/hospitals-begin-offering...

    Radiation is part of treatment for about half of cancer patients. A breakthrough could change the future of the treatment. Hospitals begin offering breakthrough radiation therapy for metastatic ...

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