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Citicoline , also known as cytidine diphosphate-choline (CDP-choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction CTP + choline phosphate ⇌ {\displaystyle \rightleftharpoons } diphosphate + CDP-choline where the two substrates of this enzyme are CTP and choline phosphate , and the two products are diphosphate and CDP-choline .
Structures and localization of the enzymes in the CDP-choline pathway. [1]: 415 The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. [1] [2] The CDP-choline pathway ...
In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction. CDP-diacylglycerol + choline CMP + phosphatidylcholine. Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline, whereas its two products are CMP and phosphatidylcholine.
The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include: Other names in common use include: 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
Acetylcholine precursors and prodrugs like choline, phosphatidylcholine , citicoline (CDP-choline), and choline alphoscerate (α-GPC) are known and have been researched. [ 45 ] References