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Colchicine is taken by mouth. [11] The injectable route of administration for colchicine can be toxic. In 2008, the US Food and Drug Administration removed all injectable colchicine from the US market. [12] [13] Colchicine has a narrow therapeutic index, so overdosing is a significant risk.
It should be considered in all patients with acute pericarditis, preferably in combination with a short-course of NSAIDs. [10] For patients with a first episode of acute idiopathic or viral pericarditis, they should be treated with an NSAID plus colchicine 1–2 mg on first day followed by 0.5 daily or twice daily for three months.
Colchicine. Limited research has shown that the anti-inflammatory drug colchicine may help stabilize Peyronie’s disease when combined with vitamin E in the early stages of the disease. The best ...
Commonly prescribed drugs are prescribed according to guidelines around the world. For instance, for ischemic heart disease, the American College of Cardiology/American Heart Association (ACC/AHA) guideline is used in the United States and the European Society of Cardiology (ESC) guideline is used in Europe.
Generally abbreviated to "P.R.N." or "PRN", pro re nata refers to the administration of prescribed medication whose timing is left to the patient (in the case of patient-controlled analgesia), nurse, or caregiver, as opposed to medication that is taken according to a fixed (primarily daily) schedule (a.k.a. "scheduled dosage").
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.