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Epigenetics & Chromatin is a peer-reviewed open access scientific journal that publishes research related to epigenetic inheritance and chromatin-based interactions. First published in 2008 by BioMed Central, its overall aim is to understand the regulation of gene and chromosomal elements during the processes of cell division, cell differentiation, and any alterations in the environment.
Embryonic stem cells exhibit dramatic and complex alterations to both global and site-specific chromatin structures. Lee et al. performed an experiment to determine the importance of deacetylation and acetylation for stem cell differentiation by looking at global acetylation and methylation levels at certain site-specific modification in histone sites H3K9 and H3K4.
By remodeling chromatin structure and changing the density of DNA packaging, gene expression can thus be modulated. [14] Chromatin remodeling occurs via post-translational modifications of the N-terminal tails of core histone proteins. [16] The collective set of histone modifications in a given cell is known as the histone code.
Epigenetic mechanisms. In biology, epigenetics is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence. [1] The Greek prefix epi-(ἐπι-"over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. [2]
Epigenetics of human development is the study of how epigenetics (hertiable characteristics that do not involve changes in DNA sequence) effects human development. Development before birth, including gametogenesis , embryogenesis , and fetal development , is the process of body development from the gametes are formed to eventually combine into ...
H3T11P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 11th threonine residue of the histone H3 protein. Histone H3 phosphorylation at threonine 11 establishes a unique chromatin mark for transcriptional control.
Epigenetic priming refers to a latent epigenetic state triggered by stimuli, such as a drug or environmental changes. The epigenetically primed state is characterized by chromatin loosening, which is the change of chromatin state from heterochromatin (tightly bound and inaccessible) to euchromatin (loosely bound and fully accessible), which leads to an increased transcription of certain genes ...
The function of DNA strands (yellow) alters depending on how it is organized around histones (blue) that can be methylated (green).. In biology, the epigenome of an organism is the collection of chemical changes to its DNA and histone proteins that affects when, where, and how the DNA is expressed; these changes can be passed down to an organism's offspring via transgenerational epigenetic ...