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  2. Hereditary haemochromatosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_haemochromatosis

    The term "haemochromatosis" is used by different sources in many different ways. It is often used to imply an association with the HFE gene. For many years, HFE was the only known gene associated with haemochromatosis, and the term "hereditary haemochromatosis" was used to describe haemochromatosis type 1. However, many different genetic ...

  3. Iron overload - Wikipedia

    en.wikipedia.org/wiki/Iron_overload

    The term hemochromatosis was initially used to refer to what is now more specifically called hemochromatosis type 1 (or HFE-related hereditary hemochromatosis). Currently, hemochromatosis (without further specification) is mostly defined as iron overload with a hereditary or primary cause, [11] [12] or originating from a metabolic disorder. [13]

  4. Hemosiderosis - Wikipedia

    en.wikipedia.org/wiki/Hemosiderosis

    Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Selective iron deposition in the beta cells of pancreatic islets leads to diabetes [ 4 ] [ 2 ] due to the distribution of transferrin receptor on the beta cells ...

  5. Hemochromatosis type 4 - Wikipedia

    en.wikipedia.org/wiki/Hemochromatosis_type_4

    Type 4 hemochromatosis is caused by mutations of the SLC40A1 gene, located on the long arm of chromosome 2, specifically at 2q32.2. The SLC40A1 gene encodes ferroportin, a protein responsible for exporting iron from cells in the intestine, liver, spleen, and kidney, as well as from reticuloendothelial macrophages and the placenta.

  6. Haemochromatosis type 3 - Wikipedia

    en.wikipedia.org/wiki/Haemochromatosis_type_3

    Treatment for hemochromatosis type 3 may include reducing iron levels by removing blood (phlebotomy), iron chelation therapy, diet changes, and treatment for complications of the disease. The purpose of the treatment is to reduce the amount of iron in the body to normal levels, prevent or delay organ damage from excess iron, and maintain normal ...

  7. HFE H63D gene mutation - Wikipedia

    en.wikipedia.org/wiki/HFE_H63D_gene_mutation

    [20] [21] The homozygous H63D variant is an indicator of the iron metabolism disorder hemochromatosis, which may increase the risk of developing a fatty liver. [22] In patients with a cirrhotic liver, the mutation can increase the rate of liver cancer .

  8. 6 Potential Long-Term Effects of Ozempic - AOL

    www.aol.com/6-potential-long-term-effects...

    6 Potential Long-Term Effects of Ozempic. You may have heard about — or maybe even experienced — the short-term side effects of Ozempic® — such as nausea, vomiting, constipation, and diarrhea.

  9. Bloodletting - Wikipedia

    en.wikipedia.org/wiki/Bloodletting

    However, in the case of hemochromatosis, bloodletting (by venipuncture) has become the mainstay treatment option. [ 43 ] [ 44 ] In the U.S., according to an academic article posted in the Journal of Infusion Nursing with data published in 2010, the primary use of phlebotomy was to take blood that would one day be reinfused back into a person ...