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In 2019 Paul Tesar, a professor at Case Western Reserve University, used CRISPR and antisense therapy in a mouse model of Pelizaeus–Merzbacher with success. [ 13 ] [ 14 ] [ 15 ] In 2022 Case Western Reserve University entered an exclusive licensing agreement with Ionis Pharmaceuticals to develop a human treatment for the disorder.
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Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease.It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane.
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English: Chart of life expectancy as a function of current age (age achieved) showing how life expectancy increases with age already achieved Data source: Actuarial Life Table. U.S. Social Security Administration Office of Chief Actuary (2020). Archived from the original on July 8, 2023.
In just the past two decades, 2000 — 2019, the average global life expectancy increased from 66.8 years to 73.4 years while healthy life expectancy has also improved by 8% over the same period.
Interactive chart of male and female life expectancy in America as defined by WHO for 2019. [5] Open the original chart and hover over chart elements. The squares of bubbles are proportional to population according to estimation of the UN for 2019.