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Epidemiologists have found evidence to suggest that long-term, high-dose supplementation with B6 and B12 may increase risk of developing lung cancer.
Compared to them, the mortality rate was 4% higher for those who took multivitamins daily and 9% higher for those who took them less often. Younger vitamin users had the highest risk.
They compared total cancer (excluding nonmelanoma skin cancer) for participants taking a daily multivitamin (Centrum Silver by Pfizer) versus placebo. Compared with placebo, men taking a daily multivitamin had a statistically significant reduction in the incidence of total cancer, with a hazard ratio (HR) = 0.92 (95% confidence interval (CI) 0. ...
The study compared total cancer (excluding non-melanoma skin cancer) for participants taking a daily multivitamin (Centrum Silver by Pfizer) versus a placebo. Compared with the placebo, men taking a daily multivitamin had a small but statistically significant reduction in their total incidence of cancer. In absolute terms, the difference was ...
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However, low vitamin B 12 status in combination with high folic acid intake, in addition to the previously mentioned neuropathy risk, appeared to increase the risk of cognitive impairment in the elderly. [105] Long-term use of folic acid dietary supplements in excess of 1,000 μg/day has been linked to an increase in prostate cancer risk. [13]