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  2. Fluoropyrimidine - Wikipedia

    en.wikipedia.org/wiki/Fluoropyrimidine

    Fluorouracil (5-FU) Tegafur; Some metabolites of these drugs, such as 5-fluorodeoxyuridylate monophosphate, also have fluoropyrimidine structures in the general sense of the term, but the more specific meaning is typically reserved for substances used as pharmaceuticals.

  3. Fluorodeoxyuridylate - Wikipedia

    en.wikipedia.org/wiki/Fluorodeoxyuridylate

    Fluorodeoxyuridylate, [1] also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation ...

  4. Tegafur - Wikipedia

    en.wikipedia.org/wiki/Tegafur

    Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. [1] It was patented in 1967 and approved for medical use in 1972. [2]

  5. Fluorouracil - Wikipedia

    en.wikipedia.org/wiki/Fluorouracil

    Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]

  6. Floxuridine - Wikipedia

    en.wikipedia.org/wiki/Floxuridine

    Floxuridine is rapidly catabolized to 5-fluorouracil, which is the active form of the drug. The primary effect is interference with DNA synthesis and to a lesser extent, inhibition of RNA formation through the drug's incorporation into RNA , thus leading to the production of fraudulent RNA.

  7. Let's predict the Oscar nominations! Who's in, who may get ...

    www.aol.com/lets-predict-oscar-nominations-whos...

    The best: Though there's no massive favorite, most of the category seems fairly obvious at this point."Anora" and "A Complete Unknown" are up for the top prizes with all the guilds (actors ...

  8. Patrick Mahomes reportedly diagnosed with 'mild' high ankle ...

    www.aol.com/sports/patrick-mahomes-reportedly...

    Kansas City Chiefs quarterback Patrick Mahomes has been diagnosed with a "mild" high ankle sprain, according to NFL Network's Ian Rapoport.. Mahomes was thought to have sustained some kind of ...

  9. There's regular-season Kelce and playoff Kelce. Regular ... - AOL

    www.aol.com/theres-regular-season-kelce-playoff...

    Patrick Mahomes has been around Travis Kelce long enough to know that there are two different versions of the tight end. There's the regular-season Trav, a Hall of Fame-worthy player in his own ...