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The last step in wet agglomeration is the final stabilization through drying. The agglomerated particles are dried to less than 5% water content, and cooled to below their glass transition temperature. [1] Wet agglomeration falls into two categories based on method of agitation: Mechanical mixing and pneumatic mixing.
The process can be very simple or very complex depending on the characteristics of the powders, the final objective of tablet making, and the equipment that is available. In the traditional wet granulation method the wet mass is forced through a sieve to produce wet granules which are subsequently dried.
Nowadays, to optimize the manufacturing process, particularly in wet granulation, various improved pieces of equipment which combines several processing steps (mixing, granulation and/or drying) are used. These are the mixer granulator and high shear mixing machine.
Low shear wet granulation processes use very simple mixing equipment, and can take a considerable time to achieve a uniformly mixed state. High shear wet granulation processes use equipment that mixes the powder and liquid at a very fast rate, and thus speeds up the manufacturing process. Fluid bed granulation is a multiple-step wet granulation ...
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations, such as milling, granulation, coating, tablet pressing, and others.
In a granulation process, only the solid component of the mixture is required. Fluid is used only as an aid to processing. The high-shear mixer processes the solid material down to the desired particle size, and the mixture is then pumped to the drying bed where the fluid is removed, leaving behind the granular product.
An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Wet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. The term wet chemistry is used as most analytical work is done in the liquid phase. [1] Wet chemistry is also known as bench chemistry, since many tests are performed at lab benches. [2]