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The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. [67] The importance of this discovery is that the expression of these genes appears in blood and can be measured by a simple blood analysis. NR1H3 Mutation.
After diagnosis of MS, characteristics that predict a worse course are male sex, older age, and greater disability at the time of diagnosis; female sex is associated with a higher relapse rate. [209] Currently, no biomarker can accurately predict disease progression in every patient. [ 205 ]
All medications are associated with adverse effects that may influence their risk to benefit profiles. [ 73 ] [ 72 ] While more studies of the long-term effects of the drugs are needed, [ 6 ] [ 71 ] [ 75 ] specially for the newest treatments, [ 17 ] [ 76 ] [ 36 ] existing data on the effects of interferons and glatiramer acetate indicate that ...
Multiple sclerosis diagnosis can only be made when there is proof of lesions disseminated in time and in space. Therefore, when damage in the CNS is big enough to be seen. It would be desirable to make it faster. The ideal diagnosis schema would be able to determine for any given subject, if he will develop MS, at any point in his life, and when.
Multiple sclerosis can be pathologically defined as the presence of distributed glial scars (or sclerosis) in the central nervous system disseminated in time (DIT) and space (DIS). [2] The gold standard for MS diagnosis is pathological correlation, though given its limited availability, other diagnosis methods are normally used. [3]
Nearly 2.3 million people are estimated to be living with multiple sclerosis around the world, but when Montel Williams received his official diagnosis back in 1999, not much was known about the ...
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