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Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person (John Cunningham) from whose tissue the virus was first successfully cultured. Publications indicate 39 [ 3 ] to 58% [ 4 ] of the general population are seropositive for antibodies to JCV, indicating current or previous infection with the virus.
To study the trajectory of weight loss using calorie restriction alone, Hall modeled the observed weight loss in the CALERIE study, which randomly assigned 238 adults to either two years of ...
Regular physical activity can help accelerate weight loss, improve metabolism and enhance the benefits of weight loss pills. Aim for 150 minutes per week (or about a half-hour five days a week).
Cindy Ord/Getty Images for SiriusXM Kelly Clarkson says she’s taking weight-loss medication, but clarified that it’s not Ozempic. Clarkson, 42, opened up about her health on the Monday, May 13 ...
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