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Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]
Uric acid is a waste product naturally made by the body when it breaks down compounds called purines. When there’s too much uric acid in the body, it can form sharp, needle-like crystals in and ...
Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their tautomers. They are the most widely occurring nitrogen-containing heterocycles in nature. [1]
Haig stated that the uric-acid free diet greatly improved his health and he had eighteen years of experience on the diet. [3] The book includes a list of forbidden foods. The uric-acid free diet explained by Haig does not permit foods that are high in purines. On this diet all meat, fish, fowl, egg yolks, beans, lentils, peas, oatmeal ...
High levels of purines are known to increase uric acid production and may aggravate or lead to conditions such as gout. [14] Harvard researchers report that omega-3 fatty acids and uridine, two substances in foods such as fish, walnuts, molasses, and sugar beets, prevented depression in rats as effectively as antidepressant drugs.
Haig's uric-acid free diet (known as Haig's diet) required the elimination of every food containing high amounts of purines that could be metabolized into uric acid. [16] On this diet all meats, legumes and some vegetables were eliminated including asparagus, beans, lentils, mushrooms, peas and whole grain products. [16]