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Allometric engineering is the process of experimentally shifting the scaling relationships, for body size or shape, in a population of organisms. More specifically, the process of experimentally breaking the tight covariance evident among component traits of a complex phenotype by altering the variance of one trait relative to another.
Allometric scaling is any change that deviates from isometry. A classic example discussed by Galileo in his Dialogues Concerning Two New Sciences is the skeleton of mammals. The skeletal structure becomes much stronger and more robust relative to the size of the body as the body size increases. [ 13 ]
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Kleiber's law, like many other biological allometric laws, is a consequence of the physics and/or geometry of circulatory systems in biology. [5] Max Kleiber first discovered the law when analyzing a large number of independent studies on respiration within individual species. [2]
Because the proportionality constants β and the scaling exponents α are often denoted using Greek letters, it is desirable to use β as the proportionality coefficient versus α, since α could be misread as the symbol for "proportional". A well-known allometric equation relates metabolic rate to body mass: Y = βM 3/4.
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The simplest PK compartmental model is the one-compartmental PK model. This models an organism as one homogenous compartment. This monocompartmental model presupposes that blood plasma concentrations of the drug are the only information needed to determine the drug's concentration in other fluids and tissues. For example, the concentration in ...