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Hyperferritinemia is usually defined by a level of total serum ferritin (TSF) exceeding 200 µg/L in women and 300 µg/L in men [1]. There are many causes of hyperferritinemia, including alcohol intake, liver disease, infection, cancer, chronic inflammation, or metabolic syndrome [2].
Extreme hyperferritinaemia greater than 3000 μg/L is uncommon in adult patients. The highest serum ferritin values are seen in HLH, but the differential diagnosis for serum ferritin greater than 3000 μg/L remains broad with iron overload and liver disease being the most common causes.
What Ferritin Level Is Dangerously High? Ferritin above 1,000 ng/mL can suggest alarming diseases, such as cancers, liver cirrhosis, and certain infections. Generally, test values over the normal range indicate iron overload. Additionally, ferritin in serum at 400 ng/mL can imply inflammation, potentially linked to the abovementioned illnesses ...
Cases of hematologic malignancy had the highest serum ferritin values: the only two ferritin values over 100,000 ng/mL (115,967 ng/mL and 143,931 ng/mL). Patients with hyperferritinemia associated with chronic transfusion displayed ferritin ranges from 10,006 ng/mL to 54,087 ng/mL.
A healthy man in his late 30s was found to have elevated ferritin levels, which raised suspicion of haemochromatosis. He was treated for many years with phlebotomy, but in his 50s developed progressive neuropsychiatric symptoms.
Outside the setting of clinical syndromes associated with iron overload (liver disease, transfusions, sickle cell syndromes), serum ferritin levels ≥1,000 ng/mL serve as a nonspecific marker for a variety of significant disorders, including infectious and neoplastic diseases.
No syndrome usually associated with extreme serum ferritin elevations was identified in 8.4% of patients, and 16.8% of the patients fell into more than one category. The highest mean serum ferritin levels occurred in the chronically transfused and sickle cell groups.
Normal serum ferritin levels vary between laboratories but generally concentrations >300 µg/L in men and postmenopausal women and >200 µg/L in premenopausal women are regarded as elevated. 1 Low ferritin values provide absolute evidence of iron deficiency. 2 Raised levels often indicate iron overload, but they are not specific, as ferritin is ...
A total of 495 patients were identified, of which 56% had a TSF level between 5000 and 10,000 g/L. There were multiple underlying causes in 81% of the patients. The most common causes were infections (38%), hemophagocytic lymphohistiocytosis (HLH, 18%), and acute hepatitis (14%).
Intensive care unit (ICU) transfer and mortality rates were recorded. A total of 495 patients were identified, of which 56% had a TSF level between 5000 and 10,000 µg/L. There were multiple underlying causes in 81% of the patients.