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An isothermal titration calorimeter is composed of two identical cells made of a highly efficient thermally conducting and chemically inert material such as Hastelloy alloy or gold, surrounded by an adiabatic jacket.
Isothermal titration calorimetry (ITC) has become the gold standard for studying molecular interactions in solution. Although it is increasingly being used in the soft matter and synthetic...
Isothermal Titration Calorimetry (ITC) elucidates the thermodynamic profile (ΔH, ΔS, ΔG, Ka, and stoichiometry) of binding and dissociation reactions in solution.
Isothermal Titration Calorimetry (ITC) is a label-free method for measuring binding of any two molecules that release or absorb heat upon binding. ITC can be used to measure the thermodynamic parameters of biomolecular interactions, including affinity (KA), enthalpy (ΔH), entropy (ΔS), and stoichiometry (n).
Isothermal titration calorimetry (ITC) is a label-free binding assay which measures the affinity, stoichiometry, and thermodynamics of molecular interactions from the reaction heat.
In this context, Isothermal Titration Calorimetry (ITC) is a powerful technique for the characterization of macromolecular interactions. ITC determines the heat change that occurs upon the binding of two molecules. Heat can be absorbed (endothermic reaction) or released (exothermic reaction).
Isothermal titration calorimetry (ITC) is a technique that measures the heat released or absorbed during a chemical reaction as an intrinsic probe to characterize any chemical process that involves heat changes spontaneously occurring during the reaction.
Isothermal titration calorimetry (ITC) is now routinely used to directly charac-terize the thermodynamics of biopolymer binding interactions and the kinetics of enzyme-catalyzed reactions. This is the result of improvements in ITC instrumen-tation and data analysis software.
Principles and design of isothermal titration calorimetry experiments. Performing an ITC experiment. Ligand in syringe. Macromolecule in sample cell. Heat of interaction is measured. Parameters measured from a single ITC experiment: Binding constant. Enthalpy. Stoichiometry. How does ITC work?
Isothermal titration calorimetry (ITC) is a very powerful technique for the thermodynamic study of intermolecular interactions, such as ligand binding to proteins or partitioning of solutes into membranes, as well as catalysis.