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C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. [ 5 ] [ 6 ] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
Inflammatory chemokines function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or tissue damage. Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing .
The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small peptide belonging to the CXC chemokine family that acts as a chemoattractant for several immune cells, especially neutrophils [5] [6] or other non-hematopoietic cells to the site of injury or infection and plays an important role in regulation of immune and inflammatory responses. It was ...
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β, renamed CCL3 and CCL4 respectively, since 2000. [ 3 ]
Chemokines are a type of cytokine that attract white blood cells to sites of inflammation or disease. CCL17 as well as its partner chemokine CCL22 induce chemotaxis in T-helper cells . [ 5 ] [ 8 ] [ 9 ] They do this by binding to CCR4 , a chemokine receptor [ 5 ] [ 8 ] [ 9 ] expressed on type 2 helper T cells, cutaneous lymphocyte skin ...
In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1). [8] The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. The CCL2 gene has three exons and two introns. The CCL2 protein precursor contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino ...
These eosinophils are strong, pro-inflammatory effector cells. The cells involved in allergic responses, such as eosinophils, are predominantly expressed through eotaxin and the CCR-3 receptor. [ 2 ] The binding of eotaxin and the other related chemokines to the CCR-3 receptor is seen to play a major role in eosinophil recruitment in allergic ...
Chemokines and their receptors play a crucial role in cancer metastasis as they are involved in extravasation, migration, micrometastasis, and angiogenesis. [4] This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site.