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Pulmonary surfactant is a surface-active complex of ... Surfactant production in humans begins in type II cells during the alveolar sac stage of lung development.
More alveolar precursors develop, and larger amounts of pulmonary surfactant are produced. Surfactant levels are not generally adequate to create effective lung compliance until about the eighth month of pregnancy. The respiratory system continues to expand, and the surfaces that will form the respiratory membrane develop further.
Surfactants are chemical compounds that decrease the surface tension or interfacial tension between two liquids, a liquid and a gas, or a liquid and a solid. The word "surfactant" is a blend of surface-active agent, [1] coined in 1950. [2]
Pulmonary surfactant is used as a medication to treat and prevent respiratory distress syndrome in newborn babies. [ 1 ] Prevention is generally done in babies born at a gestational age of less than 32 weeks. [ 1 ]
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid (and a lecithin) consisting of two C 16 palmitic acid groups attached to a phosphatidylcholine head-group.. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing.
Like synthetic surfactants, they are composed of a hydrophilic moiety made up of amino acids, peptides, (poly)saccharides, or sugar alcohols and a hydrophobic moiety consisting of fatty acids. Correspondingly, the significant classes of biosurfactants include glycolipids , lipopeptides and lipoproteins, and polymeric surfactants as well as ...
Infant respiratory distress syndrome (IRDS), also known as surfactant deficiency disorder (SDD), [2] and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfactant production and structural immaturity in the lungs.
Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, [1] is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent ...