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The drug acts by inhibiting 24-dehydrocholesterol reductase, which catalyzes the final step of cholesterol biosynthesis, the conversion of desmosterol into cholesterol. [6] Although effective in reducing cholesterol levels, this results in tissue accumulation of desmosterol, which in turn is responsible for the side effects of triparanol. [2]
The phenolic compounds and saponins in quinoa may help reduce the risk of cardiovascular disease and diabetes, and its soluble fiber helps decrease triglycerides and LDL levels in the body while ...
Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.Its development was halted in 2006 when phase III studies showed excessive all-cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib.
Reducing your intake of sugary, high-fat, and high-calorie foods and increasing your activity level can help. Try Red Yeast Rice Supplements. Many natural products out there claim to lower ...
Level of the good cholesterol HDL is also increased. Fibrates may decrease LDL, though generally to a lesser degree than statins. Similar to statins, the risk of muscle damage exists. Nicotinic acid, like fibrates, is also well suited for lowering triglycerides by 20–50%. It may also lower LDL by 5–25% and increase HDL by 15–35%.
Considered a legume, chickpeas are full of fiber which can help lower total cholesterol levels. Lentils. Another high-fiber food that can help lower cholesterol, according to the Harvard Health Blog.
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