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Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). [ 1 ] PDT is used in treating acne , wet age-related macular degeneration , psoriasis , and herpes .
Photodynamic therapy: PK Penetrating keratoplasy: POAG Primary open-angle glaucoma PPDR Preproliferative diabetic retinopathy PRA Pan-retinal ablation PRK Photorefractive keratectomy PRP Pan-retinal photocoagulation PSCC Posterior sub-capsular cataract PVD Posterior vitreous detachment PXF Pseudoexfoliative syndrome RD Retinal detachment: RK
Examples are bevacizumab (avastin) and ranibizumab. These relatively new drugs are injected into the eye. Photodynamic therapy (PDT): A photosensitive drug is ‘activated’ by strong light. Consideration may be given to combined therapy of PDT and anti VEGF.
A photosensitizer being used in photodynamic therapy. Photosensitizers are light absorbers that alter the course of a photochemical reaction. They usually are catalysts. [1] They can function by many mechanisms, sometimes they donate an electron to the substrate, sometimes they abstract a hydrogen atom from the substrate.
observation, photodynamic therapy, thermal laser, anti-VEGF therapy or combination therapy Polypoidal choroidal vasculopathy (PCV) is an eye disease primarily affecting the choroid . It may cause sudden blurring of vision or a scotoma in the central field of vision .
Photomedicine is an interdisciplinary branch of medicine that involves the study and application of light with respect to health and disease. [1] [2] Photomedicine may be related to the practice of various fields of medicine including dermatology, surgery, interventional radiology, optical diagnostics, cardiology, circadian rhythm sleep disorders and oncology.
Schematic representation of the mechanism of (a) photopharmacology (b) photodynamic therapy, and (c) optogenetics. The discovery of natural photoreceptors such as rhodopsins in the eye inspired the biomedical and pharmacology research community to engineer light-sensitive proteins for therapeutic applications. [2]
Molecular frameworks most often used as photosensitizers for antimicrobial photodynamic therapy. The examples listed in this figure include: methylene blue (MB, phenothiazine), crystal violet (CV, triarylmethane), porphyrins, phtalocyanines, riboflavin (Vitamin B 2), rose bengal (RB, halogenated xanthene), chlorins and curcumin.
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related to: photodynamic therapy in ophthalmology meaning examples