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  2. Hedgehog pathway inhibitor - Wikipedia

    en.wikipedia.org/wiki/Hedgehog_pathway_inhibitor

    The classical Hedgehog signaling pathway involves glycoproteins that are secreted by cells into the intercellular space. Multiple such glycoproteins have been characterized: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). [16] Among these, Shh is the most potent.

  3. Hedgehog signaling pathway - Wikipedia

    en.wikipedia.org/wiki/Hedgehog_signaling_pathway

    Sonic hedgehog has been shown to promote the proliferation of adult stem cells from various tissues, including primitive hematopoietic cells, [32] mammary [33] and neural [34] stem cells. Activation of the hedgehog pathway is required for transition of the hair follicle from the resting to the growth phase. [35]

  4. Sonic hedgehog protein - Wikipedia

    en.wikipedia.org/wiki/Sonic_hedgehog_protein

    6469 20423 Ensembl ENSG00000164690 ENSMUSG00000002633 UniProt Q15465 Q62226 RefSeq (mRNA) NM_000193 NM_001310462 NM_009170 RefSeq (protein) NP_000184 NP_001297391 NP_033196 Location (UCSC) Chr 7: 155.8 – 155.81 Mb Chr 5: 28.66 – 28.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sonic hedgehog protein (SHH) is a major signaling molecule of embryonic development in humans and ...

  5. Vismodegib - Wikipedia

    en.wikipedia.org/wiki/Vismodegib

    Vismodegib, sold under the brand name Erivedge, is a medication used for the treatment of basal-cell carcinoma (BCC). [3] The approval of vismodegib on January 30, 2012, represents the first Hedgehog signaling pathway targeting agent to gain U.S. Food and Drug Administration (FDA) approval. [4]

  6. PTCH1 - Wikipedia

    en.wikipedia.org/wiki/PTCH1

    PTCH1 is a member of the patched gene family and is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene functions as a tumor suppressor .

  7. Sonidegib - Wikipedia

    en.wikipedia.org/wiki/Sonidegib

    Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism). [5] [6] Approvals and indications.

  8. Review: 'Sonic the Hedgehog 3' keeps franchise spinning at ...

    www.aol.com/news/review-sonic-hedgehog-3-keeps...

    Helmed at a breakneck pace by Jeff Fowler, “Sonic the Hedgehog 3” is loud, chaotic and often corny, with a visual style that can only be described as “retina-searing,” but the script by ...

  9. Smoothened - Wikipedia

    en.wikipedia.org/wiki/Smoothened

    It also is the target of vismodegib, the first hedgehog pathway inhibitor to be approved by the U.S. Food and Drug Administration (FDA). [8] Smoothened (Smo) is a key transmembrane protein that is a key component of the hedgehog signaling pathway, a cell-cell communication system critical for embryonic development and adult tissue homeostasis.