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Erythromelalgia; Erythromelalgia in left hand: Specialty: Oncology: Causes: There was a study done in 2013 where two Vietnamese patients were diagnosed with primary erythromelalgia. Patient A was a 33-year old female diagnosed with primary erythromelalgia at age 30 and suffered from burning and pain in her feet since she was 8 years old (Wu et ...
This is a burning pain in the hands or feet, usually accompanied by a reddish or bluish coloration of the skin. Erythromelalgia is caused by an increased platelet count or increased platelet "stickiness" (aggregation), resulting in the formation of tiny blood clots in the vessels of the extremity; it responds rapidly to treatment with aspirin.
PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel Na V 1.7 encoded by the gene SCN9A .
There are also a number of other conditions that affect hands, feet, and parts of the face with associated skin color changes that need to be differentiated from acrocyanosis: Raynaud phenomenon, pernio, acrorygosis, erythromelalgia, and blue finger syndrome. The diagnosis may be challenging in some cases, especially when these syndromes co-exist.
Symptoms typically begin in the feet or hands but can start in other parts of the body. Some people initially experience a more generalized, whole-body pain. The pain is often described as stabbing or burning, or abnormal skin sensations such as tingling or itchiness. In some individuals, the pain is more severe during times of rest or at night.
Secondary Raynaud's can occur due to a connective-tissue disorder such as scleroderma or lupus, injuries to the hands, prolonged vibration, smoking, thyroid problems, and certain medications, such as birth control pills and stimulants. [8] Diagnosis is typically based on the symptoms. [3] The primary treatment is avoiding the cold. [3]
Attacks of skin redness and burning sensation or pain in one or both external ears are the only common symptoms. [1] Pain is often most pronounced at the ear lobe, and sometimes radiates to the jawbone and cheek. [1] The pain is normally mild, but has occasionally been described as severe. [1]
The main treatment for acral erythema is discontinuation of the offending drug, and symptomatic treatment to provide analgesia, lessen edema, and prevent superinfection. However, the treatment for the underlying cancer of the patient must not be neglected. Often, the discontinued drug can be substituted with another cancer drug or cancer treatment.