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Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT 4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system.
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Drug interactions [ edit ] The drug inhibits P450 and enhances the effects of terfenadine , astemizole , indinavir , midazolam , calcium channel blockers , warfarin , cisapride and ciclosporin .
Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT 3 antagonists proper, possess some weak antagonist effect at the 5-HT 3 receptor. Galanolactone, a diterpenoid found in ginger, is a 5-HT 3 antagonist and is believed to at least partially mediate the anti-emetic activity of this plant.
Later, in a study conducted with healthy adult volunteers, itopride was shown as unlikely to cause cardiac arrhythmias or ECG changes in part to the lack of significant interaction and metabolism via the cytochrome P450 enzyme pathway, unlike cisapride and mosapride, as it is metabolized by a different enzyme set.
Fatal arrhythmia, drug interactions. [2] [3] Minaprine: 1996 France Convulsions. [3] Moxisylyte: 1993 France Necrotic hepatitis. [3] Muzolimine: 1987 France, Germany, European Union Polyneuropathy. [3] Natalizumab (Tysabri) 2005–2006 US Voluntarily withdrawn from US market because of risk of Progressive multifocal leukoencephalopathy (PML ...
Mosapride is a gastroprokinetic agent that acts as a selective 5HT 4 agonist.The major active metabolite of mosapride, known as M1, additionally acts as a 5HT 3 antagonist, [1] which accelerates emptying throughout the whole of the gastrointestinal tract in humans, [2] and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia [3] and irritable bowel ...
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. [5]