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Mirikizumab, a drug currently approved by the Food and Drug Administration (FDA) for the treatment of ulcerative colitis, also sends Crohn's disease into clinical remission, new findings suggest.
“There has been a great deal of progress in developing new, more effective and safe agents to treat inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) over the last 20 years.
Mirikizumab was developed by Eli Lilly and Company. [11]The approval was based on the LUCENT 1 clinical study which evaluated the safety and efficacy of mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.
Vidofludimus is an investigational new drug that is being evaluated to treat Crohn's disease and ulcerative colitis. [1] It is a dihydroorotate dehydrogenase inhibitor. [ 2 ]
Etrasimod, sold under the brand name Velsipity, is a medication that is used for the treatment of ulcerative colitis. [6] It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the immune system. [6] It is taken by mouth. [6] The most common side effects include lymphopenia (low levels of lymphocytes ...
Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis and ulcerative colitis. [3] [4] [6] [7] It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation.
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