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Dakin's solution is a dilute solution of sodium hypochlorite (0.4% to 0.5%) and other stabilizing ingredients, traditionally used as an antiseptic, e.g. to cleanse wounds in order to prevent infection. [1] The preparation was for a time called also Carrel–Dakin solution or Carrel–Dakin fluid. [2]
An over-the-counter drug, its advertising was carried out by Warren Muller Dulubowsky. [3] By April 1989, Sterling Drug was owned by Eastman Kodak. Three Sterling brands, Haley's M-O, Philips' Milk of Magnesia, and Phisoderm, were being advertised by N.W. Ayer. [4] In 1991, the Phisoderm account was picked up by Ammirati & Puris of New York ...
During the 1960s, both were available over the counter in the US. After the ban, pHisoDerm was reformulated without hexachlorophene, and continued to be sold over-the-counter, while pHisoHex , (which contained 3% hexachlorophene - 3 times the legal limit imposed in 1972), [ 7 ] became available as a prescription body wash.
Chlorhexidine came into medical use in the 1950s [15] and is available over the counter in the United States. [9] It is on the World Health Organization's List of Essential Medicines. [16] In 2022, it was the 230th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [17] [18]
For these purposes PVP-I has been formulated at concentrations of 7.5–10.0% in solution, spray, surgical scrub, ointment, and swab dosage forms; however, use of 10% povidone-iodine though recommended, is infrequently used, as it is poorly accepted by health care workers and is excessively slow to dry. [11] [12]
Side effects may include irritation of the skin and discoloration of clothing. [2] A harsh burn on a child from an undissolved tablet has been reported. [10] For treating eczema, it is recommended using for a few days at a time due to the possibility of it irritating the skin. [10]