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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [ 8 ] [ 9 ] It may also be used for hiccups and muscle spasms near the end of life, [ 9 ] and off-label to treat alcohol use disorder [ 10 ] [ 11 ] or opioid withdrawal symptoms. [ 12 ]
Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, cerebral palsy, and multiple sclerosis. [47] Phenibut is used in Russia, Ukraine, Belarus, and Latvia to treat anxiety and improve sleep, as in the treatment of insomnia. [ 48 ]
Parasomnias are a category of sleep disorders that involve abnormal movements, behaviors, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep.
Baclofen also inhibits neural function presynaptically, by reducing calcium ion influx, and thereby reducing the release of excitatory neurotransmitters in both the brain and spinal cord. It may also reduce pain in patients by inhibiting the release of substance P in the spinal cord, as well.
Anticipate when you’re likely to feel down — and plan accordingly. We can experience “anticipatory anxiety” when we know something stressful is on the horizon, Carmichael says. “Autumn ...
Advanced sleep phase disorder (ASPD) – A condition in which patients feel very sleepy and go to bed early in the evening and wake up very early in the morning Delayed sleep phase disorder (DSPD) – Faulty timing of sleep, peak period of alertness, the core body temperature rhythm, hormonal and other daily cycles such that they occur a number ...
“Most people feel tired after a traditional Thanksgiving meal for other reasons besides the tryptophan in turkey,” says Pacheco. “Factors like alcohol, carb-heavy side dishes, ...
Drugs used to treat blepharospasm are anticholinergics, benzodiazepines, baclofen, and tetrabenazine. [43] The proportion of patients who benefited from anticholinergics ranged from 1 in 9 in Oregon [44] to 1 in 5 in England. [11] Besides failing to resolve the blepharospasm, some drugs present the risk of side effects.