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Virome refers to the assemblage of viruses [1] [2] that is often investigated and described by metagenomic sequencing of viral nucleic acids [3] that are found associated with a particular ecosystem, organism or holobiont. The word is frequently used to describe environmental viral shotgun metagenomes.
A systematic exploration of the viruses that infect humans (the human virome) is important and feasible with these methods. Polymerase chain reaction is a tool to amplify and detect specific DNA sequences. It can be used to help characterize the virome, but it is limited by the need for at least partial DNA sequence information.
One such surveillance program is the Global Virome Project (GVP) an international collaborative research initiative based at the One Health Institute at the University of California, Davis. [ 29 ] [ 30 ] The GVP aims to boost infectious disease surveillance around the globe by using low cost sequencing methods in high risk countries to prevent ...
The sequence-driven approach to screening is limited by the breadth and accuracy of gene functions present in public sequence databases. In practice, experiments make use of a combination of both functional and sequence-based approaches based upon the function of interest, the complexity of the sample to be screened, and other factors.
Diagram illustrating genomics. Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms.
Sequencing is the only diagnostic method that will provide the full sequence of a virus genome. Hence, it provides the most information about very small differences between two viruses that would look the same using other diagnostic tests. Currently it is only used when this depth of information is required.
Multiomics, multi-omics, integrative omics, "panomics" or "pan-omics" is a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome, metabolome, and microbiome (i.e., a meta-genome and/or meta-transcriptome, depending upon how it is sequenced); [1] [2] [3] in other words ...
Virosphere (virus diversity, virus world, global virosphere) was coined to refer to all those places in which viruses are found or which are affected by viruses. [1] [2] However, more recently virosphere has also been used to refer to the pool of viruses that occurs in all hosts and all environments, [3] as well as viruses associated with specific types of hosts (prokaryotic virosphere, [4 ...