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Painful red swelling of the hands and feet in a patient receiving chemotherapy is usually enough to make the diagnosis. The problem can also arise in patients after bone marrow transplants, as the clinical and histologic features of PPE can be similar to cutaneous manifestations of acute (first three weeks) graft-versus-host disease. It is ...
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Pain, swelling, bluish discoloration Paroxysmal hand hematoma , also known as Achenbach syndrome , is a skin condition characterized by spontaneous focal hemorrhage into the palm or the volar surface of a finger, which results in transitory localized pain, followed by rapid swelling and localized blueish discoloration .
Bone marrow failure in both children and adults can be either inherited or acquired. Inherited bone marrow failure is often the cause in young children, while older children and adults may acquire the disease later in life. [3] Acquired bone marrow failure may be due to aplastic anemia [4] or myelodysplastic syndrome.
The first reported case was in 1878 by Silas Weir Mitchell who suggested the term erythromelalgia to describe a syndrome of red congestion and burning pain in the hands and feet. [49] [50] Silas Weir Mitchell. He distinguished it from the painful red limbs seen in some patients with gout or rheumatoid arthritis. [49]
It can also affect the thigh, buttock, hand, abdomen, and foot. [ 19 ] [ 14 ] The most common cause of acute compartment syndrome is a fractured bone, usually the tibia . [ 14 ] [ 27 ] Leg compartment syndrome occurs in 1% to 10% of tibial fractures. [ 6 ]
Bone marrow comprises approximately 5% of total body mass in healthy adult humans, such that a person weighing 73 kg (161 lbs) will have around 3.7 kg (8 lbs) of bone marrow. [ 5 ] Human marrow produces approximately 500 billion blood cells per day, which join the systemic circulation via permeable vasculature sinusoids within the medullary ...
The resulting new bone is often called an involucrum. [13] On histologic examination, these areas of necrotic bone are the basis for distinguishing between acute osteomyelitis and chronic osteomyelitis. Osteomyelitis is an infective process that encompasses all of the bone (osseous) components, including the bone marrow.