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16191 Ensembl ENSG00000113525 ENSMUSG00000036117 UniProt P05113 P04401 RefSeq (mRNA) NM_000879 NM_010558 RefSeq (protein) NP_000870 NP_034688 Location (UCSC) Chr 5: 132.54 – 132.56 Mb Chr 11: 53.61 – 53.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Function Through binding to the ...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, T h 2 cells, eosinophils and basophils. [4]
IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF), [18] but while these exist as monomeric structures, IL5 is a homodimer. The fold contains an anti-parallel 4-alpha-helix bundle with a left handed twist, connected by a 2-stranded anti-parallel beta-sheet.
The interleukin 4 receptor is a type I cytokine receptor.It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor).
The interleukin-5 receptor is a type I cytokine receptor.It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. [1] [2]The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the ...
Interleukin 3 is an interleukin, a type of biological signal that can improve the body's natural response to disease as part of the immune system. [10] In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor.
Upon approval by the Joint Staff, DISA will work with the customer and the appropriate military department to arrange the service. [3] The Defense Red Switch Network consists of four major subsystems: the Switching Subsystem, the Transmission Subsystem, the Timing and Synchronization Subsystem, and the Network Management Subsystem.
Behind the Green Door secure communications center with SIPRNET, NMIS/GWAN, NSANET, and JWICS access. The Joint Worldwide Intelligence Communications System (JWICS) is a secure intranet system utilized by the United States Department of Defense to house "Top Secret/Sensitive Compartmented Information" [5] In day-to-day usage, the JWICS is used primarily by members of the Intelligence Community ...