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Jostel's TSH index (TSHI or JTI), also referred to as Jostel's thyrotropin index or Thyroid Function index (TFI), is a method for estimating the thyrotropic (i.e. thyroid stimulating) function of the anterior pituitary lobe in a quantitative way. [1] [2] The equation has been derived from the logarithmic standard model of thyroid homeostasis.
Thyroid's secretory capacity (G T, also referred to as thyroid's incretory capacity, maximum thyroid hormone output, T4 output or, if calculated from serum levels of thyrotropin and thyroxine, as SPINA-GT [a]) is the maximum stimulated amount of thyroxine that the thyroid can produce in a given time-unit (e.g. one second).
In healthy persons, the intra-individual variation of TSH and thyroid hormones is considerably smaller than the inter-individual variation. [39] [40] [41] This results from a personal set point of thyroid homeostasis. [42] In hypothyroidism, it is impossible to directly access the set point, [43] but it can be reconstructed with methods of ...
The National Academy of Clinical Biochemistry (NACB) stated that it expected the reference range for adults to be reduced to 0.4–2.5 μIU/mL, because research had shown that adults with an initially measured TSH level of over 2.0 μIU/mL had "an increased odds ratio of developing hypothyroidism over the [following] 20 years, especially if ...
from quantiles of FT4 and TSH concentration (as determined based on cumulative distribution functions). [1] Per definition the TFQI has a mean of 0 and a standard deviation of 0.37 in a reference population. [1] This explains the reference range of –0.74 to + 0.74.
The Thyrotroph Thyroid Hormone Sensitivity Index (abbreviated TTSI, also referred to as Thyrotroph T4 Resistance Index or TT4RI) is a calculated structure parameter of thyroid homeostasis. It was originally developed to deliver a method for fast screening for resistance to thyroid hormone .
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Deutsch: Referenzbereiche für die Sekretionsleistung der Schilddrüse (SPINA-GT) und den TSH-Index nach Jostel (TSHI oder JTI) verglichen mit univariablen Referenzbereichen für Thyreotropin (TSH) und freies Thyroxin (FT4), dargestellt im zweidimensionalen Phasenraum, der durch TSH- und FT4-Serumkonzentrationen definiert ist.