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  2. Bottom-up and top-down design - Wikipedia

    en.wikipedia.org/wiki/Bottom–up_and_topdown...

    Illustration of bottom up and top down approach to heap sort. Bottom-up and top-down are both strategies of information processing and ordering knowledge, used in a variety of fields including software, humanistic and scientific theories (see systemics), and management and organization. In practice they can be seen as a style of thinking ...

  3. Top-down - Wikipedia

    en.wikipedia.org/wiki/Top-down

    Top-down and bottom-up design of information ordering; Top-down parsing, a parsing strategy beginning at the highest level of the parse tree Top-down parsing language, an analytic formal grammar to study top-down parsers; Top-down perspective, a camera angle in computer and video games; Top-down shooter, a subgenre of video games

  4. Systems biology - Wikipedia

    en.wikipedia.org/wiki/Systems_biology

    These are the top down and bottom up approach. The top down approach takes as much of the system into account as possible and relies largely on experimental results. The RNA-Seq technique is an example of an experimental top down approach. Conversely, the bottom up approach is used to create detailed models while also incorporating experimental ...

  5. Bottom-up - Wikipedia

    en.wikipedia.org/wiki/Bottom-up

    Bottom-up parsing, a computer science strategy; Bottom-up processing, in Pattern recognition (psychology) Bottom-up theories of galaxy formation and evolution; Bottom-up tree automaton, in data structures; Bottom-up integration testing, in software testing; Top-down and bottom-up design, strategies of information processing and knowledge ordering

  6. Bottom-up proteomics - Wikipedia

    en.wikipedia.org/wiki/Bottom-up_proteomics

    There is limited protein sequence coverage by identified peptides, loss of labile PTMs, and ambiguity of the origin for redundant peptide sequences. [7] Recently the combination of bottom-up and top-down proteomics, so called middle-down proteomics, is receiving a lot of attention as this approach not only can be applied to the analysis of large protein fragments but also avoids redundant ...

  7. Top-down proteomics - Wikipedia

    en.wikipedia.org/wiki/Top-down_proteomics

    Top-down vs bottom-up proteomics. Top-down proteomics is a method of protein identification that either uses an ion trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry (MS/MS) analysis [1] [2] or other protein purification methods such as two-dimensional gel electrophoresis in conjunction with MS/MS. [3] Top-down proteomics is capable ...

  8. Fundamental analysis - Wikipedia

    en.wikipedia.org/wiki/Fundamental_analysis

    Investors using fundamental analysis can use either a top-down or bottom-up approach. The top-down investor starts their analysis with global economics, including both international and national economic indicators. These may include GDP growth rates, inflation, interest rates, exchange rates, productivity, and energy prices. They subsequently ...

  9. Grassroots - Wikipedia

    en.wikipedia.org/wiki/Grassroots

    There is an ongoing debate as to whether a bottom-up or top-down approach is better suited to address the problems facing communities. Top-down processing involves large-scale programs or high-level frameworks, often driven by governmental or international action.