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The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for screening for tuberculosis (TB) and for tuberculosis diagnosis.
According to the U.S. Centers for Disease Control, [2] in 2001, the Quantiferon-TB test (QFT) was approved by the Food and Drug Administration (FDA) as an aid for detecting latent Mycobacterium tuberculosis infection. This test is an in vitro diagnostic aid that measures a component of cell-mediated immune reactivity to M. tuberculosis.
T-SPOT.TB counts the number of antimycobacterial effector T cells, white blood cells that produce interferon-gamma, in a sample of blood.This gives an overall measurement of the host immune response against mycobacteria, which can reveal the presence of infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).
According to Nguyen Viet Nhung, director of the National Lung Hospital in Hanoi, the test is similar to RT-PCR, gives accurate results within 35–45 minutes for both COVID-19 and tuberculosis, and could work automatically. [15] It is also used for COVID-19 testing at six sites across Somalia. [16]
Contrary to this, however, studies have shown that the tine test can give results that correlate well to the Mantoux test. [ 7 ] [ 8 ] If a minor reaction is considered doubtful, the OT test is less accurate and may fail to detect TB, producing a false negative. [ 2 ]
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However, clinicians should rely on clinical judgement to diagnose TB meningitis when culture results are negative. [ 7 ] A 2007 before-after observational study found that use of the MTD test reduced inappropriate tuberculosis therapy.
Cocoa was the top-performing commodity of 2024. The price of the bean surged as headwinds battered key producers. Prices are likely to stay high into 2025, analysts at ING said.