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Cell synchrony is a vital process in the study of cells progressing through the cell cycle as it allows population-wide data to be collected rather than relying solely on single-cell experiments. The types of synchronization are broadly categorized into two groups; physical fractionization and chemical blockade.
Obtaining a culture with a unified cell-cycle stage is useful for biological research where a particular stage in the cell cycle is desired (such as the culturing of parasitized cells [3]). Since cells are too small for certain research techniques, a synchronous culture can be treated as a single cell; the number of cells in the culture can be ...
The cell cycle is a series of complex, ordered, sequential events that control how a single cell divides into two cells, and involves several different phases. The phases include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. [ 1 ]
In some experiments, a researcher may want to control and synchronize the time when a group of cells progress to the next phase of the cell cycle. [5] The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle ...
Cells are thought to time the MBT by measuring the nucleocytoplasmic ratio, which is the ratio between the volume of the nucleus, which contains DNA, to the volume of cytosol. Evidence for this hypothesis comes from experiments showing that the timing of MBT can be sped up by adding extra DNA [ 4 ] to make the nucleus larger, or by halving the ...
A syncytium (/ s ɪ n ˈ s ɪ ʃ i ə m /; pl.: syncytia; from Greek: σύν syn "together" and κύτος kytos "box, i.e. cell") or symplasm is a multinucleate cell that can result from multiple cell fusions of uninuclear cells (i.e., cells with a single nucleus), in contrast to a coenocyte, which can result from multiple nuclear divisions without accompanying cytokinesis. [1]
When the period has expired, the cell is updated and the timer reset. Updating is autonomous and proceeds at different rates for different cells. The self-sync scheme - the same as the clocked scheme, but the phase of the timers are affected by local coupling to neighbours, and so are able to achieve local synchrony.
Maywood and collaborators showed that VIP-null host SCN cells synchrony deteriorated over time based on the mean vector length of the Raleigh plots decreasing, and concluded that paracrine signaling from an introduced wild-type SCN graft is sufficient to restore the synchrony between SCN cell pacemakers based on the mean vector length ...