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  2. Naloxegol - Wikipedia

    en.wikipedia.org/wiki/Naloxegol

    Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol.Specifically, the 6-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG, shown extending at the lower left of the molecule image at right.

  3. Methylnaltrexone - Wikipedia

    en.wikipedia.org/wiki/Methylnaltrexone

    Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

  4. Peripherally acting μ-opioid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Peripherally_acting_μ...

    Even though μ-opioid receptor (MOR) targeting drugs have been used for a long time, not much is known about the structure-activity relationship and the ligand-receptor interactions on the basis of well-defined biological effects on receptor activation or inhibition. Also, the distinction in the receptor-ligand interaction patterns of agonists ...

  5. Alvimopan - Wikipedia

    en.wikipedia.org/wiki/Alvimopan

    Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid receptor antagonist.With the limited ability to cross the blood–brain barrier and reach the μ-opioid receptors of the central nervous system, the clinically undesirable effects of centrally acting opioid antagonists (like reversal of opioid-mediated analgesia) are avoided without affecting the intended ...

  6. New drug's potentially fatal side effects obscured by ... - AOL

    www.aol.com/news/drugs-potentially-fatal-side...

    The association said that “one key question” taken up by the roundtable was whether ARIA was a temporary symptom of the new drug — much the way nausea and hair loss are side effects of ...

  7. Naldemedine - Wikipedia

    en.wikipedia.org/wiki/Naldemedine

    Naldemedine, sold under the brand name Symproic in the US and Rizmoic in the European Union, is a medication that is used for the treatment of opioid-induced constipation in adults who have previously been treated with a laxative in the European Union, or to treat opioid induced constipation in adults with chronic non-cancer pain in the US.

  8. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

    www.aol.com/cialis-side-effects-expect-avoid...

    Cialis Drug Interactions. Tadalafil side effects aren’t the only concern when taking this drug. As mentioned, Cialis can interact with other PDE5 inhibitors for ED, as well as medications ...

  9. Study retracted years after it set off an infamous COVID-19 ...

    www.aol.com/news/study-retracted-years-set-off...

    A discredited study that set off a flurry of interest in using an antimalarial drug to treat COVID-19 has now been formally withdrawn. A scientific journal on Tuesday retracted the March 2020 ...