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  2. What Should I Do If Viagra Is Not Working for Me? - AOL

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    Here’s why you may find Viagra is not working for you. You’re Not Using Viagra Correctly. We don’t want to point any fingers, but one reason Viagra may not work for you is because you’re ...

  3. Is Sildenafil Safe for This Common Male Problem? - AOL

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    More does not necessarily equal better, and it’s important to stick to your prescription. Use it strategically. Sildenafil is most effective when taken at least 30 minutes to one hour before ...

  4. Things You Probably Don't Know About Viagra (Like What ... - AOL

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    Viagra usually starts working 30 to 60 minutes after taking it. But simply swallowing the little blue pill won’t automatically make you hard — you still have to be aroused, either through ...

  5. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Sildenafil acts by blocking phosphodiesterase 5 (PDE 5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. [8]

  6. What Happens If You Take Viagra and You Don't Need It? - AOL

    www.aol.com/happens-viagra-dont-105800158.html

    If you struggle with ED, drugs like Viagra®, sildenafil, tadalafil, and other FDA-approved medications could help with your performance. But if you’re not prescribed one of these meds, taking ...

  7. Discovery and development of phosphodiesterase 5 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection. That side effect soon became the main field of investigation. [23] The inhibitor is highly selective for the PDE5 family. [22] Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra.

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