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Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk. It is influential in over 300 separate processes in various vertebrates, including humans. [5] Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation and ...
The number for prolactin cells in a pregnant female will increase to allow for breast tissue development. Prolactin is involved in the maturation of mammary glands and their secretion of milk in association with oxytocin, estrogen, progesterone, glucocorticoids, and others. Prolactin has numerous other effects in both sexes. [citation needed]
Elevated prolactin blood levels are typically assessed in women with unexplained breast milk secretion (galactorrhea) or irregular menses or infertility, and in men with impaired sexual function and milk secretion. If high prolactin levels are present, all known conditions and medications which raises prolactin secretion must be assessed and ...
This pathway controls the secretion of certain hormones, including prolactin, from the pituitary gland. [9] "Infundibular" in the word "tuberoinfundibular" refers to the cup or infundibulum, out of which the pituitary gland develops. regulation of prolactin secretion [10] hyperprolactinaemia [10] Hypothalamospinal tract
Prolactin, a major hormone of the HPP axis.. The hypothalamic–pituitary–prolactin axis (HPP axis), also known as the hypothalamic–pituitary–mammary axis or hypothalamic–pituitary–breast axis, is a hypothalamic–pituitary axis which includes the secretion of prolactin (PRL; luteotropin) from the lactotrophs of the pituitary gland into the circulation and the subsequent action of ...
Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). [1] Agonists of the dopamine D 2 receptor such as bromocriptine and cabergoline are able to strongly suppress pituitary prolactin secretion and thereby decrease circulating prolactin levels, and so are most commonly used as prolactin inhibitors. [1]
The production and release of the neuropeptide VIP is centralized in the hypothalamic and extrahypothalamic regions of the brain and from there it is able to modulate the release of prolactin secretion. [24] Once secreted from the pituitary gland, prolactin can increase many behaviors such as parental care and aggression.
· Somatostatin: inhibits GH (and other hormone) secretion · Gonadotropin releasing hormone (GnRH): stimulates FSH and LH secretion · Prolactin releasing hormone (PRH): stimulates PRL secretion · Prolactin inhibiting hormone (dopamine): inhibits PRL secretion These hypothalamic hormones are secreted in pulse.