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Warfarin inhibits the vitamin K-dependent synthesis of biologically active forms of the clotting factors II, VII, IX and X, as well as the regulatory factors protein C, protein S, and protein Z. [85] [86] Other proteins not involved in blood clotting, such as osteocalcin, or matrix Gla protein, may also be affected.
Warfarin – a coumarin – with brand name, Coumadin, is a prescription drug used as an anticoagulant to inhibit formation of blood clots, and so is a therapy for deep vein thrombosis and pulmonary embolism. [9] [10] [11] It may be used to prevent recurrent blood clot formation from atrial fibrillation, thrombotic stroke, and transient ...
See warfarin for a more detailed discovery history. Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin ...
Coumarin (/ ˈ k uː m ər ɪ n /) or 2H-chromen-2-one is an aromatic organic chemical compound with formula C 9 H 6 O 2.Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by an unsaturated lactone ring −(CH)=(CH)−(C=O)−O−, forming a second six-membered heterocycle that shares two carbons with the benzene ring.
Pharmaceutical-grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestines or bovine (cattle) lungs. [103] Advances to produce heparin synthetically have been made in 2003 and 2008. [104] In 2011, a chemoenzymatic process of synthesizing low molecular weight heparins from simple disaccharides was ...
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver.It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites.
8529 72054 Ensembl ENSG00000186115 ENSMUSG00000003484 UniProt P78329 Q99N16 RefSeq (mRNA) NM_001082 NM_024444 RefSeq (protein) NP_001073 NP_077764 Location (UCSC) Chr 19: 15.88 – 15.9 Mb Chr 8: 72.74 – 72.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 4F2 is a protein that in humans is encoded by the CYP4F2 gene. This protein is an enzyme, a type of protein ...